Lazio vs. Torino (Tuesday, 5.30pm)
While Turin's second side are dealing with the consequences of a COVID-19 outbreak within their squad - which saw their training ground closed and previous fixture postponed - the home side must prepare as usual, despite the possibility the game may not go ahead.
We say: Lazio 2-0 Torino
Should the authorities see fit for this game to go ahead, there is only one likely outcome that a depleted Torino team can expect.
Lazio are in need of a tonic, to wash away the troubles of last week and keep themselves in contention for a return to European competition next season. If they can stem a recent flood of self-inflicted defensive errors, then the Biancocelesti have more than enough firepower available to punish a makeshift Toro team at the Olimpico.
Juventus vs. Spezia (Tuesday, 7.45pm)
Andrea Pirlo's side are still adrift of the league-leading Milan clubs after a draw in Verona at the weekend, while their Bianconeri counterparts staged a second-half fightback to salvage a point against Parma.
We say: Juventus 2-0 Spezia
The plucky visitors may have a good track record against the bigger boys this term, but their progressive approach is likely to come unstuck against Juventus, as the home side are particularly unimpeachable on Turin turf.
With Aaron Ramsey overdue a telling contribution and Federico Chiesa continuing to offer a flicker of hope, some of the champions' supporting cast can step up to lift a little weight off Cristiano Ronaldo's broad shoulders.