Sears and Murphy will start together up top, with support coming a little deeper from Chaplow in midfield, while Gerken returns in goal for Mick McCarthy's team.
The visitors have also decided to leave out loan signing Chris Long despite two debut goals recently, with Andre Gray starting in attack as a lone striker.
Ipswich Town: Gerken, Parr, Mings, Chambers, Smith, Berra, Skuse, Murphy, Chaplow, Tabb, Sears
Brentford: Button; Bidwell, Douglas, Odubajo, Dallas, Judge, Gray, Diagouraga, Pritchard, Moore, Tarkowski
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