Parma vs. Napoli (Wednesday, 6.30pm)
Parma currently occupy 14th spot with 40 points to show from 34 matches, whereas Napoli are sixth on 56 points with four games left to go.
We say: Parma 1-2 Napoli
Napoli could be without two key attacking figures in Milik and Mertens for the trip to Parma, but the hosts have been in woeful form and have injury problems of their own to contend with, so we are backing Napoli to walk away with all three points in midweek.
Lecce vs. Brescia (Wednesday, 8.45pm)
We say: Lecce 2-1 Brescia
Lecce have a more realistic chance than Brescia of staying up and will be confident of picking up a victory here against their travel-sick opponents. Defeat could be enough to send the visitors down and we are expecting that to be the case.
Inter Milan vs. Fiorentina (Wednesday, 8.45pm)
Fiorentina make the trip to San Siro having put together a five-match unbeaten streak, which has included three wins and two draws.
We say: Inter Milan 2-1 Fiorentina
Taking Inter's inconsistency into account, we expect Fiorentina to play with a confidence which suggests that they have total belief in gaining a result on Wednesday night. However, motivated to remain in the title hunt, Inter could snatch all three points during the closing stages.
Sampdoria vs. Genoa (Wednesday, 8.45pm)
Both sides enjoyed victories at the weekend, with Sampdoria overcoming Parma 3-2 while Genoa picked up a vital three points in a 2-1 win at home to Lecce.
We say: Sampdoria 3-1 Genoa
Even though Genoa have now enjoyed two victories from their last three, those triumphs were over fellow relegation candidates and they were incredibly fortunate to take the spoils against Lecce. Nicola's men have struggled against the sides above them and Sampdoria are performing well at the minute, so we are going for a comfortable home victory.
Torino vs. Hellas Verona (Wednesday, 8.45pm)
Il Toro have won two of their last four games and are eight points above the dropzone with four games to go, while Verona are 12 points off a European spot.
We say: Torino 2-2 Hellas Verona
Torino are more in need of points than Verona on Wednesday evening and have won back-to-back games at home. However, Verona have a habit of frustrating sides and we can see that being the case again here.
SPAL vs. Roma (Wednesday, 8.45pm)
Roma will be aiming to consolidate their hold on fifth spot when they travel to already-relegated SPAL in Serie A on Wednesday evening.
In contrast, SPAL's relegation from the top flight has already been confirmed and the division's basement side have little to play for in the final couple of weeks.
We say: SPAL 0-3 Roma
SPAL will no doubt want to try and end their season on a high note following an otherwise dismal campaign, but Roma are enjoying a strong spell of form and should record all three points against Serie A's basement side with little difficulty on Wednesday.