The champions, who won their first top-flight title last season, will hope that club-record signing Musa gets off the mark alongside Vardy, who scored 24 league goals in the 2015-16 campaign.
Newly-promoted Hull face a difficult start to their season as they are still without a permanent manager - Mike Phelan is in temporary charge - and a string of injury problems has resulted in just three substitutes being named on the bench.
Eldin Jakupovic starts in goal, with Ahmed Elmohamady, Curtis Davies and Andrew Robertson in defence alongside Jake Livermore, who has had to drop back from midfield because of the injury-ravaged squad.
Hull City: Jakupovic; Elmohamady, Livermore, Davies, Robertson; Huddlestone, Meyler, Snodgrass, Clucas; Hernandez, Diomande
Subs: Kuciak, Tymon, Maloney
Leicester City: Schmeichel; Simpson, Hernandez, Morgan, Fuchs; Drinkwater, King, Mahrez, Gray; Musa, Vardy
Subs: Zieler, Chilwell, Albrighton, Amartey, Kapustka, Okazaki, Ulloa
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