The Suffolk area has seen heavy snowfall and freezing temperatures, with more of the same forecast for Friday evening.
Although the playing surface at Portman Road was expected to be suitable for football by 3pm on Saturday, surrounding access routes near the stadium are likely to be closed.
"Due to the current extreme weather conditions, Saturday's away game against Ipswich Town has been postponed," read a statement on the Hull website.
"The decision was taken on Friday morning, with further heavy snow and freezing temperatures forecast for the Ipswich area overnight and into tomorrow. Although the Portman Road pitch would likely have been playable come 3pm on Saturday, the surrounding access routes are deemed to be unsafe for those attending the game."
The fixture will be rescheduled "in due course", and all ticket holders will be granted admission on the new date.
Sheffield United against Burton Albion has also been postponed due to the weather, along with five matches in League One and four games in League Two.