Laurent Depoitre starts as a lone striker, taking the place of Steve Mounie, while an attacking three includes incoming Abdelhamid Sabiri alongside Tom Ince and Elias Kachunga as Rajiv van La Parra drops to the bench.
Craig Shakespeare makes two changes from the 2-1 defeat against Chelsea for his visiting Foxes. Kelechi Iheanacho makes his full debut up front as Islam Slimani drops to the bench, while Ben Chilwell replaces Matty James further back.
Huddersfield Town: Lossl; Smith, Jorgensen, Schindler, Lowe; Mooy, Williams; Kachunga, Sabiri, Ince; Depoitre
Subs: Coleman, Malone, Hogg, Billing, Van La Parra, Hefele, Quaner
Leicester City: Schmeichel; Simpson, Morgan, Maguire, Chilwell; Albrighton, Ndidi, King, Mahrez; Vardy, Iheanacho
Subs: Hamer, Dragovic, Amartey, Gray, Iborra, Slimani, Okazaki