Rafael Benitez makes just two changes from the side that came from behind to claim a 2-1 win at automatic promotion rivals Brighton & Hove Albion on Tuesday evening.
Diame is joined in the midfield by Matt Ritchie, Jack Colback, Jonjo Shelvey and Christian Atsu, while 20-goal top scorer Dwight Gayle starts the game on the bench after missing the game against the Seagulls with a hamstring injury.
There is one change in the back four as Vurnon Anita comes in for DeAndre Yedlin at right-back, with Jamaal Lascelles and Ciaran Clark continuing their partnership in the heart of the defence and Paul Dummett operating on the left.
For the hosting Terriers, head coach David Wagner makes two alterations to the starting XI that managed a 1-1 draw at Barnsley last weekend and 10 changes from the side that went down 5-1 at Manchester City in their FA Cup replay in midweek.
Huddersfield Town: Ward; Smith, Hefele, Schindler, Lowe; Billing, Mooy; Kachunga, Brown, Van La Parra; Wells
Subs: Coleman, Hudson, Hogg, Cranie, Payne, Lolleu, Quaner
Newcastle United: Darlow; Anita, Lascelles, Clark, Dummett; Ritchie, Shelvey, Diame, Colback, Atsu; Murphy
Subs: Elliot, Yedlin, Gamez, Hanley, Gouffran, Perez, Gayle