The two teams go into the match in 22nd and 23rd place respectively, with just one point separating them ahead of kickoff.
A win for either could move them out of the drop zone, potentially as high as 18th place depending on how other fixtures play out.
Peterborough are one of the division's form sides, with no defeats in their last last seven games, a run which has given them every chance of avoiding relegation.
Huddersfield, who go into the game off the back of two defeats, are likely to be without the services of full-back Jack Hunt, who picked up an injury mid-week.
Possible starting lineups
Huddersfield: Smithies, Dixon, Norwood, Clarke, Gerrard, Scannell, Gobern, Ward, Danns, Lynch, Vaughan
Peterborough: Olejnik, Alcock, Zakuani, Little, Rowe, Newell, Ferdinand, Knight-Percival, Payne, Tomlin, Gayle
Sports Mole says: 1-2