The Hatters returned to winning ways in midweek to climb up to ninth in the table, three points better off than Huddersfield, who have lost three of their last four.
Luton have carried their form from the end of last season into this one and may well be an outside contender to finish in the playoffs.
As boss Nathan Jones pointed out following the 1-0 victory over Rotherham United in the week, which leaves Luton one place off the top six, the table does not lie.
Jones's side have now won back-to-back away matches by that same scoreline, with James Collins netting his fifth goal of the campaign to earn the win at the New York Stadium.
In fact, Town have won five of their last seven away league games, which is as many as their previous 24 combined beforehand.
Huddersfield are pointless in their last two home matches, meanwhile, losing 2-1 to Preston North End and Bristol City.
Those losses sandwiched a far better performance in the 3-0 win away at Millwall, but Carlos Corberan will now be after a bit more consistency from his side.
The Terriers have won back-to-back league games only once since February, and this is a fixture that they struggled in last season as they lost home and away.
That was Luton's first double over Huddersfield since 2002-03, and they are now seeking successive away wins against their opponents for the first time ever.
For that to happen they may well have to score more than once - something that they have done only once in their last nine games in all competitions - as Huddersfield have netted in each of their last eight league matches.
Huddersfield Town Championship form: WWLLWL
Luton Town Championship form: LLWDLW
Josh Koroma was on the scoresheet again last time out and has now scored three times in his last six league matches - as many as he managed in his first 41 EFL outings.
In terms of the visitors, Matty Pearson was back involved in the win against Yorkshire rivals Rotherham and should retain his spot at right-back here.
Collins was on Thursday called up to the Republic of Ireland squad for their upcoming fixtures and will be looking to add to the goal that he scored against Rotherham.
Huddersfield Town possible starting lineup:
Hamer; Stearman, Schindler, Sarr; Pipa, Hogg, Eiting, Toffolo; Mbenza, Campbell, Koroma
Luton Town possible starting lineup:
Sluga; Pearson, Rea, Bradley, Cranie; Morrell, Tunnicliffe; Cornick, Berry, Moncur; Collins
We say: Huddersfield Town 1-2 Luton Town
Luton have won back-to-back away Championship matches, while Huddersfield have lost their last two games at the John Smith's Stadium.
The Hatters also took six points from six in this fixture last term, so we are backing them to keep their momentum going with another win in Yorkshire.