The Yellow Submarine have won their last two in the league to rise into seventh spot in the table, while Granada occupy ninth, just two points behind their opponents here.
Promoted as Segunda Division runners-up last season, Granada have not finished higher than 15th in Spain's top flight since the 1973-74 campaign but are chasing a potential European spot this time around.
Indeed, a total of 42 points from 29 matches has left El Grana in ninth spot in the table, two points behind seventh-placed Villarreal and just four points off Atletico Madrid in sixth.
Diego Martinez's side have only lost one of their last eight in the league, picking up four wins in the process to leave themselves comfortably in the top half of the division.
They recorded a 2-1 win over Getafe on their return to action after the lockdown period on June 12 before picking up a point away to Real Betis on Monday night.
Villarreal, meanwhile, have won both their matches since returning to action on June 13, first recording a 1-0 victory at Celta Vigo before beating Mallorca by the same scoreline on Tuesday night.
The Yellow Submarine entered the lockdown period off the back of three straight defeats but have picked up two important victories since to leave themselves in seventh position in the table.
As it stands, Javi Calleja's side are only two points off sixth-placed Atletico and three behind Getafe in fifth, while they sit just three off fourth-placed Real Sociedad in the race for Champions League football.
Villarreal did not finish outside of the top six in La Liga between 2013 and 2018 but ended last season in 14th and will therefore be determined to claim a European spot this time around.
The two teams played out a 4-4 draw in the reverse game at the Estadio de la Ceramica back in August, while they also shared the points in a 1-1 draw when they last locked horns at the home of Granada in 2016.
Granada La Liga form: WWDDWD
Granada form: (all competitions) WDWDWD
Villarreal La Liga form: WLLLWW
Granada were without Colombian midfielder Yangel Herrera against Betis through suspension, but the 22-year-old is available for this match and should return to the XI.
Vicente Iborra is back from suspension, though, and should return to the middle of the park.
Granada possible starting lineup:
Silva; Foulquier, Sanchez, Vallejo, Neva; Eteki, Herrera; Machis, Vito, Puertas; Fernandez
Villarreal possible starting lineup:
Asenjo; Gaspar, Albiol, Quintilla, Moreno; Cazorla, Iborra, Trigueros; Moreno, Bacca, Chukwueze
We say: Granada 1-1 Villarreal
Both of these sides will be eyeing a European finish in Spain's top flight, meaning that it is set to be a very interesting battle on Friday night. Both teams have been in good form since returning to action, and we are therefore finding it hard to separate them, ultimately backing a 1-1 draw.