The Borussia Dortmund defender is suffering with flu and has been replaced in the starting lineup by Shkodran Mustafi.
Elsewhere, it is as expected for the Germans as they look to continue their record of always reaching the last eight of the World Cup.
Germany: Neuer; Mustafi, Mertesacker, Boateng, Howedes; Schweinsteiger, Lahm, Kroos; Ozil, Muller, Gotze
Algeria: Mbolhi; Ghoulam, Belkalem, Halliche, Mandi; Lacen, Soudani, Taider, Mostefa, Feghouli; Slimani
Follow our minute-by-minute updates on the match in Porto Alegre by clicking here.