Joachim Low's side recorded a 2-1 victory over Ukraine on Saturday to move onto five points in the section, while Switzerland suffered a 1-0 defeat to Spain on the same night to remain bottom of the group.
Germany started their League A Group 4 campaign with back-to-back draws against Spain and Switzerland but recorded a 2-1 win over Ukraine on Saturday night.
Die Mannschaft finished bottom of their section in the 2018-19 edition of the Nations League, picking up just two points from their four matches against the Netherlands and France.
Germany comfortably qualified for next summer's European Championships, though, winning seven of their eight matches to finish top of Group C ahead of the Netherlands.
DFB-Elf lead the overall head-to-head record over Switzerland 35 wins to nine, but the points were shared in a 1-1 draw when they locked horns towards the start of September.
Switzerland, as mentioned, will enter the match off the back of a 1-0 defeat to Spain on Saturday, with Mikel Oyarzabal scoring the only goal of the contest in the 14th minute.
Vladimir Petkovic's team are currently bottom of Group 4, having picked up just one point from their three matches, losing to Ukraine and Spain, in addition to drawing with Germany on home soil.
Switzerland impressed during the 2018-19 edition of this tournament, topping a section that included Belgium before losing to eventual winners Portugal in the semi-finals.
Nati then lost to England on penalties in the third-place playoff after a goalless draw, but they will be present at next summer's European Championships, having topped Group D ahead of Denmark.
Germany Nations League form: LLDDDW
Germany form (all competitions): WWDDDW
Switzerland Nations League form: WLLLDL
Switzerland form (all competitions): WWLDLL
Liverpool's Xherdan Shaqiri was expected to miss out after recently testing positive for coronavirus, but the attacker has since returned a negative test and was involved off the bench against Spain, meaning that he could come into the starting XI on Tuesday night.
Germany possible starting lineup:
Neuer; Can, Sule, Rudiger; Klostermann, Kimmich, Kroos, Halstenberg; Gnabry, Werner, Havertz
Switzerland possible starting lineup:
Sommer; Benito, Rodriguez, Schar, Elvedi, Widmer; Sow, Xhaka, Freuler; Seferovic, Shaqiri
We say: Germany 2-0 Switzerland
Switzerland gave Spain a tough examination on Saturday and were impressive in their 1-1 draw with Germany last month. Low's team will be determined to put back-to-back victories on the board, though, and we fancy the hosts to secure all three points in Cologne.