Die Mannschaft have been present in the semi-finals in each of the last two European Championships but have not actually lifted the trophy since Euro 1996.
The visitors will be the overwhelming favourites to triumph on Saturday night. However, the only other previous meeting between Belarus and Germany ended in a 2-2 draw back in 2008.
Here, Sports Mole looks at how Germany could line up this weekend.
Germany are expected to keep the 3-4-3 formation that served them well against the Netherlands. However, one of the back three from that match - Antonio Rudiger - is unavailable, which could mean a start for Jonathan Tah alongside Matthias Ginter and Niklas Sule.
Further forward, Thilo Kehrer and Nico Schulz could again operate in the wing-back positions either side of Joshua Kimmich and Ilkay Gundogan, with the latter potentially coming in for the injured Toni Kroos.