Fiorentina start with Amauri and Stevan Jovetic in attack as they look to avenge their humiliating 5-0 defeat to Juventus last week.
Juan Vargas starts in midfield for Delio Rossi, accompanied by Riccardo Montolivo and Valon Behrami.
Former Viola player Sebastien Frey and Alberto Gilardino feature for the hosts, along with former AC Milan defender Kakha Kaladze.
Genoa: Amelia; Frey, Kaladze, Carvalho, Moretti, Mesto, Veloso, Belluschi, Biondini, Rossi, Palacio, Gilardino
Fiorentina: Boruc, Natali, Gamerbini, Pasqual, Cassani, Montolivo, Behrami, Vargas, Marchionni, Amauri, Jovetic
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Genoa
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