Antonio is ahead of schedule in his recovery from a hamstring problem but will not be fit in time, while captain Noble suffered a rib injury in training.
On-loan striker Said Benrahma, who scored a brace against Fulham for Brentford in the Carabao Cup last month, could make his full debut.
Lemina was substituted at half-time during Fulham's 2-0 victory over West Brom on Monday with a slight strain and it remains to be seen whether the midfielder will be fit enough by Saturday.
Provisional West Ham squad: Fabianski, Balbuena, Ogbonna, Cresswell, Coufal, Masuaku, Rice, Soucek, Bowen, Benrahma, Haller, Randolph, Fredericks, Diop, Snodgrass, Lanzini, Fornals, Yarmolenko.
Provisional Fulham squad: Areola, Aina, Andersen, Adarabioyo, Robinson, Anguissa, Reed, Decordova-Reid, Cairney, Lookman, Mitrovic, Rodak, Odoi, Ream, Loftus-Cheek, Keebano, Bryan, Cavaleiro.