The German winger and the club's record signing make their Premier League debuts alongside five other new signings as the Cottagers mark their return to the top flight after a four-year absence.
Calum Chambers, Joe Bryan, Maxime Le Marchand, Fabricio and Aleksandar Mitrovic - now on a permanent contract after his move from Newcastle United - are the other newcomers to be included from the off as Fulham try to extend a run of unbeaten opening-day games at home that stretches back to 1989.
Roy Hodgson, who signed a one-year extension with Palace this week, sticks with tried-and-tested players in his starting XI as the Eagles aim to resume their six-match unbeaten run from the end of the previous campaign.
Fulham: Fabricio; Christie, Chambers, Le Marchand, Bryan; McDonald, Cairney, Seri; Schurrle, Mitrovic, Sessegnon
Subs: Rico, Kebano, Johansen, Vietto, Fosu-Mensah, Cisse, Kamara
Crystal Palace: Hennessey; Wan Bissaka, Tomkins, Sakho, Van Aanholt; Townsend, Milivojevic, McArthur, Schlupp; Benteke, Zaha
Subs: Guaita, Ward, Kouyate, Sorloth, Souare, Kelly, Riedewald
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