The Arsenal forward is given the nod up top once again by manager Didier Deschamps, as Les Bleus run out for the final time ahead of next Friday's opening Euro 2016 meeting with Romania at the Stade de France.
Despite Antoine Griezmann being available following his Champions League exerts with Atletico Madrid last weekend, and Anthony Martial also shaking off a knock to take a place in the squad, Giroud is the focal point in attack.
It is close to what is expected to be Deschamps's starting lineup for the Euros, showing just one change from last time out with the inclusion of N'Golo Kante in midfield, with Kingsley Coman arguably most at risk of losing his place to the returning Griezmann.
Scotland boss Gordon Strachan has made five changes from last week's defeat to Italy, meanwhile, bringing Andrew Robertson, Gordon Greer, Robert Snodgrass, Shaun Maloney and Steven Fletcher - who spent the second half of last season on loan in France with Marseille - back into the starting fold.
These two sides have met 15 times before; Scotland winning eight and France coming out on top seven times.
France: Lloris, Sagna, Rami, Koscielny, Evra, Pogba, Kante, Matuidi, Coman, Payet, Giroud
Subs: Mandala, Costil, Jallet, Digne, Mangala, Umtiti, Cabaye, Schneiderlin, Sissoko, Gignac, Griezmann, Martial
Scotland: Marshall, Martin, Greer, Hanley, Robertson, D.Fletcher, McArthur, Snodgrass, Maloney, Ritchie, S.Fletcher
Subs: Fox, Hamilton, Mulgrew, Kingsley, Paterson, Bryson, Anya, Phillips, Burke, McGinn, McKay, Naismith, McCormack
Follow all of the action as it unfolds in Metz with Sports Mole's live text coverage right here.