Sassuolo have played out a couple of entertaining six-goal draws in their last two matches and are three points better off than Fiorentina, who sit directly below them in 13th.
Roberto De Zerbi's side showed incredible fighting spirit in their high-scoring draws with Inter and Hellas Verona, scoring late on in both matches to rescue a point.
The manner of his team's defending in those games will surely be of concern to Zerbi, however, and they also shipped four goals in their first match back against Atalanta BC.
Two points from the nine on offer since the three-month hiatus - and one win in five going further back - has killed off Sassuolo's outside chances of finishing in a European spot.
The Neroverdi are eight points behind AC Milan in seventh, while the gap on the dropzone is nine points, suggesting that they are now merely jostling for position in mid-table.
The same is also true for Fiorentina, who have drawn 1-1 with Brescia and lost 2-1 away at Lazio in their first two games back.
In fact, since thrashing Sampdoria 5-1 on February 16, Giuseppe Iachini's side have drawn three and lost one of their four matches.
Fiorentina have particularly struggled in home games this term, drawing six, losing five and winning only three times at Stadio Artemio Franchi - their worst return since 1970-71.
Sassuolo have picked up all three points just twice in their last 10 away league outings, however, and have conceded seven goals in the last two of those matches.
La Viola recovered from a goal down to win the reverse fixture 2-1 in October, making it two wins apiece and two draws over the last six encounters.
Successive wins in this fixture will be the aim for Iachini on Wednesday. A failure to achieve that aim and relegation can still not be entirely ruled out for his side.
Fiorentina's Serie A form: LWDLDD
Fiorentina's form (all competitions): WWDLDD
Sassuolo's Serie A form: WLWLDD
Federico Chiesa is back from suspension for Fiorentina, while head coach Iachini is also back in the dugout after serving a ban of his own last time out.
Fiorentina possible starting lineup:
Dragowski; Venuti, Milenkovic, Pezzella, Dalbert; Duncan, Pulgar, Castrovilli; Chiesa, Cutrone, Ribery
Sassuolo possible starting lineup:
Consigli; Muldur, Marlon, Ferrari, Rogerio; Locatelli, Obiang; Berardi, Defrel, Boga; Caputo
We say: Fiorentina 1-1 Sassuolo
These sides are separated by just one place in the table and are both seeking a first win since returning to action. If their recent encounters are anything to go by then a tight contest can be expected in Florence on Wednesday, one that we are expecting to finish level.