Zwolle, on the other hand, will be looking to exact revenge on their visitors after a 5-1 trashing in October's reverse fixture.
Twente failed to win at home for the 10th consecutive game as they succumbed to a 2-1 defeat against Vitesse on Saturday.
The Tukkers remain eighth in the Eredivisie table, but they continue to lose ground on the teams around them in the race for European football qualification.
Saturday's visitors have the fourth-best away record in the division, and perhaps another game on the road is what they need to get back on their feet.
Zwolle were unable to make it back-to-back victories as they were agonisingly beaten 3-2 away at Sparta Rotterdam on Saturday.
There was to be one final twist as Lennart Thy netted a 15-minute brace which included a 93rd-minute winner to leave the visitors empty-handed.
The Blauwvingers remain in 13th place after the defeat, but they are now just seven points away from the relegation zone.
However, there are only six matches left to play, and it is highly unlikely that they will get sucked into any relegation scrap.
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Mees Hilgers has had just 15 minutes of playing time with the senior team so far, and he is ruled out for the game despite recently recovering from a hip injury.
Max Bruns was named among the substitutes last time out, but he is not expected to be rushed back into action having only just come back from a calf problem.
Slobodan Tedic has scored in each of the hosts' last two outings and continues to impress since returning from a rib injury.
Sai van Wermeskerken put in a superb performance for Zwolle against Groningen, but that came at a personal cost as he sustained a calf injury.
PEC Zwolle possible starting lineup:
Zetterer; Nakayama, Van Polen, Kersten, Paal; Huiberts, Lam, Reijnders; Tedic, Buitink, Misidjan
FC Twente possible starting lineup:
Drommel; Dumic, Staring, Pierie, Ebuehi; Zerrouki, Roemeratoe, Bosch; Menig, Danilo, Van Leeuwen
We say: PEC Zwolle 1-1 FC Twente
Both teams are in need of a lift having undergone rough patches in recent weeks. While a draw may not be ideal for either side, we are backing a share of the spoils in this one, with the teams cancelling each other out.