The right-back was ruled out of Thursday's win over San Marino and it remains to be seen if he will be cleared to play this weekend, while Marcus Rashford has returned to Manchester United with a foot injury and Bukayo Saka will not take part due to a hamstring issue.
Nick Pope maintained his perfect England record against San Marino and will be eyeing his sixth clean sheet from six Three Lions appearances here, while Manchester United duo Harry Maguire and Luke Shaw could replace Conor Coady and Ben Chilwell in defence.
John Stones and Reece James were both hooked at half time in midweek so are sure to reprise their roles here, and Mason Mount was also granted a rest after 45 minutes of Thursday's 5-0 win and should man the engine room once more.
Jude Bellingham impressed off the bench at Wembley but is unlikely to challenge James Ward-Prowse for a start in midfield, although one alteration in the middle could see Declan Rice come back in for Kalvin Phillips.
Jesse Lingard was frustrated by San Marino goalkeeper Elia Benedettini throughout the evening but will hope to be given another chance to find the back of the net here, while Raheem Sterling should keep his spot on the left over Phil Foden.
Dominic Calvert-Lewin and debutant Ollie Watkins enjoyed themselves with three goals between them on Thursday, but Harry Kane - who has scored in all of England's last seven qualifying matches for the Euros or World Cup away from home - is well-rested and will likely lead the line.
England possible starting lineup:
Pope; James, Stones, Maguire, Shaw; Rice, Mount, Ward-Prowse; Lingard, Kane, Sterling