The visitors come into this game after losing on the opening day of the campaign last week, while Eibar find themselves top of the table after winning their first game of the season.
Eibar have been handed a second chance at La Liga football of sorts after their reprieve from relegation last season.
Armeros finished 18th in the table but avoided the drop after 13th-placed Elche were relegated instead as a punishment for financial mismanagement.
The Basque side embarked on their first ever campaign as a top-flight club last term and earned much praise for the way they performed, despite having by far and away the smallest wage budget in the league.
At the halfway point of the season they were as high as eighth, but a poor run of form in the second half of the campaign saw them drop into the relegation zone.
Having escaped an immediate return to the Segunda Division by the skin of their teeth, Jose Luis Mendilibar's side will be looking to push on and avoid another relegation battle this time around.
Recent league form: W
Bilbao have had a busy start to the new season, playing no less than seven competitive fixtures already due to Europa League and Spanish Super Cup commitments.
Ernesto Valverde's side opened up their league campaign against Barcelona, whom they had beaten just a week before to lift the Super Cup. However, there was to be no repeat against the Catalans, as Luis Suarez gave them a 1-0 win at San Mames.
Either side of the clashes with Barcelona, Bilbao faced Zilina across two legs for a place in the group stages of the Europa League.
A seventh-placed finish was a good return for Bilbao last season and they will be looking to emulate that at the least this term.
Recent league form: L
Recent form (all competitions): WDLLW
Eibar have no injury concerns ahead of this match and could go with the same side that saw off Granada.
Milan loanee Simone Verdi had to settle for a place on the bench in that one and Mendilibar might be tempted to keep him there and not alter a winning team.
Iraizoz and Rico are likely to come back into the side, but Balenziaga looks set to miss out. Centre-backs Mikel San Jose and Xabier Etxeita could make their comebacks from injury, with former Eibar man Eneko Boveda starting at right-back.
Aritz Aduriz, who bagged three goals in the two games with Zilina, is expected to lead the line for the visitors.
Eibar possible starting lineup:
Irureta; Ramis, Escalente, Capa, Sergi; Dani, Dos Santos, Luna, Keko, Saul; Adrian
Athletic Bilbao possible starting lineup:
Iraizoz; Boveda, Etxeita, San Jose, Marcos; Benat, Jose; Susaeta, Erato, Merino; Aduriz
Head To Head
The teams have met four times in the past, with three draws and the only win so far going to Bilbao.
Eibar held Bilbao to a credible draw in the first league meeting between the teams at San Mames last September.
We say: Eibar 1-2 Athletic Bilbao
Eibar will be buoyed by their victory over Granada last week, but Bilbao offer a completely different test and the hosts will have to be at their best to win. The visitors have more competitive football under their belts this season and that extra sharpness should be enough to earn them the victory.