That result handed Liverpool the Premier League title, and the Blues could take a step towards silverware of their own if they reach the semi-finals on Sunday.
Here, Sports Mole rounds up Chelsea's latest injury and suspension news ahead of the contest.
Status: Major doubt
Type of injury: Ankle
Possible return date: June 28 (vs. Leicester)
Callum Hudson-Odoi was once again absent for the match against Man City as he continues to struggle with an ankle injury and, while a cup match would ordinarily be a good chance for him to get minutes, this quarter-final may come just too soon for him.
Type of injury: Muscle
Possible return date: July 1 (vs. West Ham United)
Fikayo Tomori is not too far away from recovering from the muscle injury which has kept him out since the restart so far, but he will not be available for Sunday's contest.
Type of injury: Knee
Possible return date: Unknown
Marco van Ginkel last played for Chelsea in 2013 but clearly remains in their plans having signed a one-year extension to his contract at Stamford Bridge this week. The 27-year-old has not played a competitive match of any kind for almost two years now due to a hellish spell out through injury.
CHELSEA'S SUSPENSION LIST
Chelsea have no players suspended for this cup tie.