The Belgian has scored three goals in Premier League fixtures versus Wolverhampton Wanderers and Leeds United, earning him the nod down the middle of the attack.
Kai Havertz does not feature in the squad, presumably because of injury, and Timo Werner is only named on the substitutes' bench with Mason Mount and Christian Pulisic getting the nod as Lukaku's support act.
Thomas Tuchel has opted to select Trevoh Chalobah on the right-hand side of the back three ahead of Cesar Azpilicueta, who is on the substitutes' bench, and Andreas Christensen, who misses out entirely.
Liverpool: Alisson; Alexander-Arnold, Konate, van Dijk, Robertson; Henderson, Thiago, Keita; Diaz, Salah, Mane
Subs: Kelleher, Milner, Firmino, Gomez, Jones, Jota, Tsimikas, Origi, Matip
Chelsea: Mendy; Chalobah, Silva, Rudiger; James, Jorginho, Kovacic, Alonso; Mount, Pulisic; Lukaku
Subs: Arrizabalaga, Kante, Werner, Loftus-Cheek, Saul, Barkley, Ziyech, Azpilicueta, Sarr