The Ivorian has been chosen ahead of Fernando Torres, who start on the bench for the Blues.
Meanwhile, Gary Cahill will partner John Terry in defence following David Luiz's hamstring injury.
Gerard Pique is the main omission for Barca, with Javier Mascherano picked alongside Carles Puyol at the back.
Xavi Hernandez and Andres Iniesta both start in midfield, while Lionel Messi heads the attack.
Chelsea: Cech; Ivanovic, Cahill, Terry, Cole; Lampard, Mikel, Ramires, Mata, Meireles; Drogba
Subs: Turnbull, Essien, Torres, Malouda, Bosingwa, Kalou, Sturridge
Barcelona: Valdes; Dani Alves, Puyol, Mascherano, Adriano; Busquets, Xavi, Iniesta; Fabregas, Messi, Sanchez
Subs: Pinto, Pique, Thiago, Keita, Pedro, Bartra, Cuenca