Roberto Di Matteo's men go to Shakhtar Donetsk and although the Blues have never faced a Ukrainian outfit, Shakhtar are used to facing English competition. Most recently they defeated Arsenal at home in 2010 and they have won three out of four home ties against English opposition.
Shakhtar are also in irresistible league form, having won all 12 of their matches to top the Ukrainian Premier League by 12 points.
Selection-wise, Di Matteo will be able to call upon John Terry as his FA ban does not apply to European competition.
Henrik Mkhitaryan is likely to lead the Shakhtar line, having already netted twice in this year's competition.
Possible starting lineups:
Shakhtar: Pyatov; Rat, Kucher, Rakitskiy, Srna; Teixeira, Fernandinho; Willian, Hubschman, llsinho; Mkhitaryan
Chelsea: Cech; Ivanovic, Cahill, Luiz, Cole; Mikel, Lampard; Mata, Oscar, Hazard; Torres
Sports Mole says: 1-1