The Argentina international scored twice on his final Premier League outing for the Citizens last weekend to take his goals tally in Sky Blue to 260 in 389 games.
Aguero has an outside chance of starting the showdown with domestic rivals Chelsea in Porto, though he is more likely to be used as a substitute at best.
Ahead of the all-English final at the Estadio do Dragao - and indeed Aguero's swansong ahead of a likely move to Barcelona - Sports Mole looks at the 32-year-old's past record against the Blues.
Against no side has Aguero scored more goals against in his career than Chelsea, finding the net 15 times in 22 appearances against them in all competitions.
That includes a hat-trick when City beat Chelsea 3-0 in the Premier League six seasons ago, and another when Pep Guardiola's men thumped the West London outfit 6-0 in the Premier League in February 2019, despite having earlier missed an open goal.
However, the Argentinian striker has not scored in three league games against them since, including both encounters this season, while he was not part of the squad for the FA Cup semi-final last month.
Indeed, Aguero fluffed a Panenka at the Etihad earlier this month before Chelsea went on to snatch a 2-1 win.
The first of Aguero's goals for City against Chelsea came in a 2-1 league win at the Etihad Stadium in March 2012, and the most recent was that aforementioned hat-trick in 2018-19.
The prolific marksman also netted a couple of goals against his favourite opponent for Atletico Madrid in a Champions League group clash in 2009-10.
On top of the 15 goals scored against Chelsea - 10 in the Premier League, two in the Champions League, two in the Community Shield and one in the FA Cup - Aguero also has three assists in this fixture, all in the English top flight.