The visitors will enter the match off the back of successive wins in the league and Copa del Rey respectively, but Celta, who had been in excellent form under their new manager, have now lost their last two.
Celta entered last Saturday's clash with Real Madrid in excellent form, having won six and lost just one of their eight matches under new head coach Eduardo Coudet, which had seen them rise up the table.
Celta would have been looking to return to winning ways in the Copa del Rey on Tuesday night, but they suffered a surprise 5-2 defeat to Segunda Division B outfit Ibiza.
Even with the recent disappointment, the home side currently sit eighth in La Liga with a record of six wins, five draws and six defeats from 17 matches, which has allowed them to collect 23 points.
Celta are only actually five points off fifth-placed Barcelona, meanwhile, and have been victorious in three of their last four matches with Villarreal in Spain's top flight.
Villarreal, meanwhile, will enter the match off the back of a 4-1 win over Zamora in the second round of the Copa del Rey on Tuesday; Unai Emery rung the changes for the contest but his team were still far too strong for the Segunda Division B side.
The Yellow Submarine recorded a 2-1 victory over Levante in the league last weekend, meanwhile, to move onto 29 points for the season, which has left them in fourth position in the table.
Emery's side, who have only lost two of their 17 league games this term, would move into third if they manage to triumph on Friday evening, and there is no question that a return to the Champions League spots is on the agenda.
El Submarino Amarillo have actually only won two of their eight La Liga matches on the road this season, though, scoring just eight times in the process, which is not quite top-four form.
Villarreal's recent record against Celta is also poor, but they did record a 1-0 victory when the two teams last locked horns in the latter stages of the 2019-20 campaign.
Celta Vigo La Liga form: WWWDWL
Celta Vigo form (all competitions): WWDWLL
Villarreal La Liga form: DDWDLW
Villarreal form (all competitions): WWDLWW
Head coach Coudet will make wholesale changes from the side that started against Ibiza, with Santi Mina, Brais Mendez, Denis Suarez, Lucas Olaza and Nestor Araujo among those expected to return, but Miguel Baeza, Fran Beltran and Okay Yokuslu could keep their positions in the side.
Carlos Bacca's goal on Tuesday could see the experienced striker earn a spot in the final third of the field ahead of Fer Nino, while Samuel Chukwueze will also be hoping to retain his spot in a wide area.
Celta Vigo possible starting lineup:
Blanco; Mallo, Murillo, Araujo, Olaza; Beltran, Yokuslu, Baeza; D Suarez; Mendez, Mina
Villarreal possible starting lineup:
Asenjo; Pena, Albiol, Torres, Pedraza; Parejo, Trigueros, M Gomez; Chukwueze, Bacca, G Moreno
We say: Celta Vigo 1-2 Villarreal
Celta have had a recent blip after an excellent run of form under their new manager, and the home side will be missing some key individuals on Friday night. A draw would be our prediction if Celta had both Aspas and Nolito available, but we are backing Villarreal to pick up an important three points here.