While the Bluebirds are now in contention for the Championship playoffs, Huddersfield are looking to stay clear of the relegation zone after claiming just one win since the turn of the year.
When Cardiff made the decision to replace Neil Harris with McCarthy, few supporters would have been satisfied with the appointment of a man who failed to win over fans at Ipswich Town.
As it stands, the Bluebirds hierarchy looked to have pulled off a masterstroke, with the former Republic of Ireland boss having guided the club to 24 points from a possible 30.
Such has been Cardiff's transformation that any draw under McCarthy is now regarded as a disappointment, highlighting the unforeseen change of mood at the Welsh outfit.
With 12 matches still remaining and some of their rivals possessing games in hand, Cardiff should still be regarded as outsiders when it comes to claiming a playoff place.
Nevertheless, Tuesday night's 4-0 win over Derby County was emphatic, and McCarthy will see no reason why his players cannot replicate that performance against an out-of-sorts Huddersfield.
Having avoided defeat against relegation rivals Birmingham City, Carlos Corberan will be content with the Terriers adding another point to their tally.
However, the 1-1 draw took Huddersfield's tally for 2021 to six points from 12 matches, their only victory coming versus promotion chasers Swansea City.
The Yorkshire side are just a couple of wins away from re-entering the mix for the mid-table spots, positions now deemed desirable after the inconsistency since the turn of the year.
With Huddersfield still possessing the eighth-best home record in the division, Corberan and his players may relish the tag of underdogs as they come up against the form team in the division.
Huddersfield Town Championship form: LLWLLD
Cardiff City Championship form: WWWWDW
Providing that he sticks with a back four, Corberan could name the same Huddersfield side which started the fixture against Blues.
Cardiff will be forced into at least one change with Joe Bennett sustaining a knee injury against Derby in midweek.
Huddersfield Town possible starting lineup:
Schofield; Edmonds-Green, Stearman, Sarr, Pipa; Bacuna, Vallejo, O'Brien; Holmes, Campbell, Mbenza
Cardiff City possible starting lineup:
Phillips; Morrison, Flint, Nelson; Ng, Vaulks, Pack, Bagan; Ojo, Bacuna; Moore
We say: Huddersfield Town 0-2 Cardiff City
Huddersfield have shown on plenty of occasions this season that they are capable of defeating any level of opposition at the John Smith's Stadium. However, we expect Cardiff to make relatively light work of their hosts, easing to a comfortable win with a clean sheet.