The Selecao overcame Peru twice at this summer's tournament and are favourites to make it three wins from three against Los Incas in the past three months.
It has been a busy year for Brazil so far, with Wednesday's match being their 12th outing of a season which will go down as their most successful for more than a decade.
Tite's side lifted ther first piece of international silverware since 2007 during this summer's Copa America, beating Bolivia, Paraguay, Argentina and Peru (twice) en route to the title.
Indeed, Brazil's good form stretches all the way back to last summer's World Cup, having won 14 and drawn three of their 17 games since their disappointing quarter-final exit at the hands of Belgium.
The five-time World Cup winners have kept 13 clean sheets in that time too, although their usually watertight defence was undone twice in their first game since the Copa America triumph when Colombia earned a 2-2 draw in Miami on Saturday.
It was matters at the other end of the field which made the headlines on that occasion, though, with Neymar returning to create one and score another on his first appearance since June.
The addition of their talisman to a squad which has already won the Copa America would make Brazil favourites against most teams in world football, and Peru must now find a way to stop a team against whom they conceded eight times during the tournament.
Ricardo Gareca's side certainly improved as the Copa America progressed, bouncing back from their 5-0 group-stage defeat to Brazil to beat Uruguay and Chile and reach the final for the first time since 1975.
Peru have since lost back-to-back games, though, following their defeat in the final with a 1-0 reverse against Ecuador on Friday night.
That defeat was somewhat misleading, though, with Los Incas allowing just that one shot on target while creating nine chances of their own, although their failure to convert those will clearly be a concern.
Not since 2013 have Peru been beaten three times in a row and their national team is in better shape now than it has been for decades, although Wednesday's match might still be a step too far for them to get back to winning ways.
Brazil form: DWWWWD
Peru form: WLWWLL
The Paris Saint-Germain forward's current record stands at 61 goals in 98 games for his country - just behind Ronaldo's record of 62 in 98 - and one more goal will leave him behind only Pele in the scoring stakes.
The likes of Gabriel Jesus, Everton Soares, Alisson Becker and Fernandinho are missing from the squad for this round of fixtures, but there is no shortage of quality with Roberto Firmino, Dani Alves and Thiago Silva among those involved.
Brazil possible starting lineup:
Ederson; Alves, Marquinhos, Silva, Sandro; Arthur, Casemiro, Coutinho; Neres, Firmino, Neymar
Peru possible starting lineup:
Gallese; Advincula, Santamaria, Abram, Trauco; Tapia, Gonzales; Costa, Cueva, Flores; Ruidiaz
We say: Brazil 2-0 Peru
Brazil are on a fine run of form this year and, with the star power of Neymar back in their ranks, should have more than enough to see off a Peru team missing two of their key players.