Marco Rose's side have lost to Bayer Leverkusen and drawn with Werder Bremen in their last two games to drop down into fourth position in the table, while Berlin sit 13th with 31 points to show from their 28 matches.
Gladbach recorded a 3-1 victory over Eintracht Frankfurt on their return to Bundesliga action on May 16, but there is no getting away from the fact that the team's last two results have been disappointing.
Indeed, they suffered a 3-1 home defeat to Leverkusen on May 23 before being held to a goalless draw by struggling Werder Bremen on Tuesday night.
Sixteen wins, five draws and seven defeats - that is how Gladbach have performed in the league this season, with a total of 53 points leaving them in fourth, two points off third-placed RB Leipzig.
Rose's team lost 2-0 when they faced Berlin in the reverse match earlier this season, but they have the third-best home record in the Bundesliga this season behind Borussia Dortmund and Bayern Munich and will fancy their chances of putting an important three points on the board this weekend.
Last season's playoff success saw Berlin promoted to the Bundesliga for the first time in their history, and Urs Fischer's side have certainly shown that they can compete at this level.
Indeed, a total of 31 points from 28 matches has left the newly-promoted outfit in 13th spot in the table, four points clear of 16th-placed Fortuna Dusseldorf on the same number of games.
Fischer's team are far from safe when it comes to the threat of relegation, though, and they have only picked up one point from their three matches since the Bundesliga resumed in the middle of May.
Indeed, successive defeats to Bayern Union and Hertha Berlin were followed by a 1-1 draw against Mainz on Wednesday night, and the capital outfit will be determined to put another three points on the board as soon as possible.
Borussia Monchengladbach Bundesliga form: WLWWLD
Union Berlin Bundesliga form: WDLLLD
Union Berlin form (all competitions): DLLLLD
Jonas Hofmann is in line to return to the XI, meanwhile, after starting on the bench against Bremen.
Borussia Monchengladbach possible starting lineup:
Sommer; Lainer, Ginter, Elvedi, Bensebaini; Kramer, Nauhaus; Hofmann, Stindl, Thuram; Plea
Union Berlin possible starting lineup:
Gikiewicz; Subotic, Schlotterbeck, Friedrich; Trimmel, Gentner, Mees, Ryerson; Bulter, Andersson, Ingvartsen
We say: Borussia Monchengladbach 2-0 Union Berlin
Gladbach will be determined to bounce back this weekend after two disappointing results, and we are finding it difficult to look past the home side. Berlin have the second-worst away record in Germany's top flight this season and could be in for a tough afternoon at Borussia-Park.