However, despite Dortmund's indifferent start in the league, a victory in midweek could see them climb to the top of the table.
Meanwhile, struggling Stuttgart travel to Signal Iduna Park with just one point to show from their opening four matches of the season.
The Reds, who are one point from safety, have lost their last three Bundesliga games, including a 2-0 defeat at home to Hoffenheim on Saturday.
Sebastian Kehl could return for the hosts after recently suffering a groin problem, but Henrikh Mkhitaryan has been ruled out with a fractured bone in his foot. Stuttgart have no fresh injury problems ahead of the encounter.
Possible starting lineups
Dortmund: Weidenfeller; Piszczek, Ginter, Papastathopoulos, Durm; Jojic, Bender; Aubameyang, Kagawa, Grosskreutz; Ramos
Stuttgart: Ulreich; Klein, Schwaab, Rudiger, Sakai; Leitner, Oriol Romeu, Gentner; Didavi; Harnik, Werner
Sports Mole says: 2-0