Jurgen Klopp's men have clinched wins from all four of their league matches, while Saturday's opponents secured their first win of the season before the international break with a 4-0 victory over Eintracht Braunschweig.
However, their goal threat could be needed even more this weekend as striker Robert Lewandowski is expected to be on the sidelines after hurting his knee while on duty for Poland.
Borussia Dortmund: WWWW
Hamburger SV: DLLW
Possible starting lineups
Borussia Dortmund: Weidenfeller; Grosskreutz, Subotic, Hummels, Schmelzer; Bender, Sahin, Blaszczykowski; Kehl, Reus; Mkhitaryan
Hamburger SV: Adler; Djourou, Westermann, Diekmeier, Lam; Calhanoglu, Arslan, Badelj, Jiracek; Beister, Zoua
Sports Mole says: 2-1