The Blues will suffer relegation to the third tier of English football if they lose at the Reebok Stadium, while a draw would require Doncaster Rovers to lose at Leicester City to ensure safety.
Zigic, who has scored seven times for Birmingham this season, has been preferred to Federico Macheda.
Bolton: Lonergan; Mills, Ream, Threlkeld, Wheater; Spearing, Trotter, Hall, Danns, Lee; Beckford
Birmingham: Randolph; Spector, Mullins, Robinson, Reilly; Huws, Adeyemi, Caddis; Burke, Zigic, Novak
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