Nothing could separate the two sides in the first leg at La Bombonera last week, with the tie ending goalless after 90 minutes, meaning a spot in the final is still completely up for grabs at Vila Belmiro.
There was a sense of bemusement after the end of the first leg, with many around the globe expecting quite a bit more from two of South America's most high-profile, attacking outfits.
In fact, the most high-tempo moment in the fixture occurred after the referee had blown the final whistle, with the Santos team bus getting stoned by suspected Boca fans.
Fortunately, no one was harmed, but this is not the first time that tensions have run high outside the ground during significant Copa Libertadores ties.
As for the game itself, both sides looked pretty evenly matched as they grappled with one another for any kind of advantage going into the decisive second leg.
Both sides were in action during the weekend, with Cuca's Santos emerging victorious from the San-Sao derby, edging past their league-leading rivals Sao Paulo with a single goal at the Morumbi.
Against Argentinos Juniors, Azul y Oro drew 2-2, making it their third draw in as many games.
Boca boss Miguel Angel Russo may well feel somewhat dissatisfied with his team's recent form, but if past results are anything to go by, the former Argentine midfielder will be well aware that history is on his side.
After all, prior to last week, Boca had won both of their 21st-century encounters against Santos.
Even more significant for Boca, these two wins came in the Copa Libertadores final back in 2003.
Santos Copa Libertadores form: WWLDWD
Santos form (all competitions): LWWDDW
Boca Juniors Copa Libertadores form: WWWLWD
Boca Juniors form (all competitions): WWWDDD
Lucas Braga was the only player not to be rested by Cuca during his side's trip across Sao Paulo to the Morumbi, making their victory all the more impressive.
Much like Cuca, Russo opted to rest a number of his key players ahead of this week's game.
Russo will be hard-pressed not to offer a start to Ramon Abila, who, left out of the starting XI in the first leg, has now scored four goals in three consecutive league games for Azul y Oro.
Another player who could be granted more of a starring role in this tie is Mauro Zarate, who has also become a trusted attacking threat in recent weeks.
Santos possible starting lineup:
Furtado; Para, Verissimo, Peres Petroni, Jonatan; Pituca, Alison, Braga; Marinho, Jorge, Soteldo
Boca Juniors possible starting lineup:
Andrada; Jara, Lopez, Izquierdos, Fabra; Capaldo, Gonzalez, Salvio, Villa; Abila, Tevez
We say: Santos 0-1 Boca Juniors
Statistically, it was almost impossible to separate these two sides in the first leg, and this week's game is expected to be just as fiercely contested. We think Boca will inch it in the end, with either Abila or Carlos Tevez providing the heroics.