The German club will host the Portuguese side at the BayArena in the first leg of their Europa League last-32 tie.
"We know all about Benfica's strengths," he told FIFA.com. "They're far from being a no-name team.
"But we're Bayer Leverkusen and we have no reason to be afraid. We can overcome this obstacle.
"I'm sure Benfica would have liked a different draw. If we play to our strengths we'll be able to handle this tough assignment."
Bayer will head into Thursday's match on the back of a 3-3 away draw with Borussia Monchengladbach in the Bundesliga on Saturday.