The Bundesliga club, who will go through as group winners with a victory in Lisbon, must also do without German international midfielder Lars Bender (stomach).
Benfica, who will finish bottom of Group C regardless of the outcome at the Estadio Da Luz, are without defensive talisman Luisao through suspension.
Benfica: Artur, Lisandro Lopez, Andre Almeida, Cesar, Benito, Cristante, Derley, Lima, John, Pizzi, Tiago
Bayer Levekusen: Leno, Spahic, Hilbert, Boenisch, Toprak, Rolfes, Calhanoglu, Castro, Bellarabi, Drmic, Kruse
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