Ronald Koeman's side have taken 15 points from the last available 15 to rise above reigning champions Real Madrid into second position in the table, but the Catalan giants are still 10 points behind runaway leaders Atletico Madrid, who also have a game in hand.
Barca will also enter this match off the back of a 5-3 win over Granada in the Copa del Rey, which saw them book their spot in the semi-finals of the competition.
Here, Sports Mole looks at how the visitors could line up against Manuel Pellegrini's team.
Barca will again be without the services of Ansu Fati, Gerard Pique and Philippe Coutinho through injury, while Sergi Roberto has suffered a relapse of a muscular problem and is facing another spell on the sidelines.
Koeman will make changes from the side that started against Granada in the Copa del Rey on Wednesday, with Sergino Dest and Clement Lenglet likely to return to the back four alongside Jordi Alba and Ronald Araujo.
Sergio Busquets was suspended for last weekend's 2-1 win over Athletic Bilbao, but the midfielder featured in the cup on Wednesday and should now return to the league XI on Sunday night, joining Frenkie de Jong in the middle of the park.