The Catalan club's form has been indifferent in recent weeks but after earning a creditable draw away at Real Madrid in the Copa del Rey in midweek, they will be confident of overcoming Valencia.
Valencia are currently in seventh place in the La Liga table but they know that they could potentially move up to fourth place if results go their way this weekend.
However, they must continue to make do without striker Roberto Soldado, who remains on the sidelines with an hamstring injury.
Possible starting lineups
Valencia: Diego Alves; Ricardo Costa, Rami, Joao Pereira, Victor Ruiz; Guardado, Banega, Costa, Valdez; Jonas, Piatti
Barcelona: Valdes; Puyol, Dani Alves, Pique, Jordi Alba; Fabregas, Iniesta, Xavi, Busquets, Pedro; Messi
Sports Mole says: 1-3