Ronald Koeman's side have beaten Dynamo Kiev, Osasuna and Ferencvaros in their last three matches, scoring 11 times and conceding zero,during an impressive run of form.
The Catalan giants have only picked up 14 points from their nine league games this term, though, and are currently down in seventh position in Spain's top flight.
Here, Sports Mole looks at how Barca could line up against the newly-promoted side.
Barca still have serious injury problems at the back, with Samuel Umtiti, Ronald Araujo, Gerard Pique and Sergi Roberto all unavailable for selection once again.
Ousmane Dembele was on the scoresheet in the European Cup and could retain his spot, potentially joining Coutinho, Messi and Antoine Griezmann in the final third of the field, meaning that Pedri could miss out.
Sergio Busquets played another 45 minutes on Wednesday night as he recovers from a knee issue, and the experienced midfielder should now be ready to feature in the XI this weekend.
Martin Braithwaite made it four goals in his last three appearances with a strike against Ferencvaros, meanwhile, but the 29-year-old is likely to be back on the bench against Cadiz.