The Blaugrana are ahead of Real Madrid on goal difference going into the weekend and will be hoping to bounce back from a disappointing draw with local rivals Espanyol in their last La Liga fixture.
However, their preparation for this match has been far from ideal, with the club sacking manager Ernesto Valverde and replacing him with Quique Setien just six days before they play host to 10th-placed Granada, who beat them 2-0 in the reverse fixture in September.
Here, Sports Mole rounds up Barcelona's latest injury and suspension news ahead of the La Liga clash.
Type of injury: Knee
Possible return date: May 10 (vs. Real Valladolid)
Luis Suarez was ruled out for four months this weekend after learning the full damage of a knee injury he picked up during Barcelona's Supercopa de Espana defeat to Atletico Madrid. The Uruguayan is set to return to full fitness in May.
Type of injury: Hamstring
Possible return date: February 13 (vs. Getafe)
Ousmane Dembele has been missing from the Barcelona squad since November and is now closing in on a return. The French winger will be out for a further month and could be reintroduced against Getafe.
Type of injury: Groin
Possible return date: January 20 (vs. Valencia)
The Brazilian midfielder Arthur has been out since December and will sit out the match against Granada too. However, he should be able to make his return against Valencia the following weekend.
BARCELONA'S SUSPENSION LIST
Return date: January 25 (vs. Valencia)
Frenkie De Jong picked up a one-game suspension against Espanyol when he was sent off for two bookable offences. If selected, the Dutchman will make his return against Valencia.