However, Barcelona were able to return to winning ways at the weekend, with a 2-0 victory being recorded at fellow Catalan side Girona.
Ernesto Valverde has a number of decisions to make ahead of this fixture, and here Sports Mole looks at how Barcelona could line up against their La Liga rivals.
Barcelona remain with Rafinha, Samuel Umtiti and Ousmane Dembele due to injury, but Valverde is still likely to make changes for their upcoming game.
Kevin-Prince Boateng could come back into the starting lineup with Luis Suarez dropping down to the bench, while Malcom may replace Philippe Coutinho providing that the youngster does not leave on a loan deal before the end of the month.
However, Lionel Messi is expected to play a role from the start given the current aggregate score, and the backline could remain the same from the weekend.