Benfica, who began their Champions League Group G campaign with a 0-0 draw against Celtic, have not lost in their domestic league this season.
In Barcelona they face a team who sits top of La Liga with six wins from six and a side who has lost just three of their last 24 away fixtures in the Champions League.
The last time Barcelona faced Portuguese opposition was in 2011 when they secured the UEFA Super Cup with a 2-0 victory over Porto.
Benfica: Artur; Pereira, Garay, Jardel, Melgarejo; Salvio, Aimar, Perez, Gaitain; Rodrigo, Lima
Barcelona: Valdes; Alves, Puyol, Mascherano, Abidal; Xavi, Busquets, Fabregas; Iniesta, Messi, Villa
Sports Mole says: 1-2