However, Barca travel to Belarus looking to protect their lead at the top of Group E and fresh from scoring in seven consecutive European away games.
BATE coach Aleksandr Yermakovich has admitted that he made a fateful error when preparing his side to meet Barcelona four years ago.
The mistake was that he "overloaded the team with tactical details" before facing the Blaugrana, which led to two heavy defeats.
Yermakovich is hoping to take a different tack by deciding to limit his team "to the minimum", in terms of tactics.
BATE also come into this game on the back of securing a 10th consecutive domestic title, with a 2-0 away win at Vitebsk.
However, the coach of the Belarusian champions has warned Barca that his team play differently in Europe and will hope to finally register a first victory over the Catalan giants.
Recent form: WLLW
Recent form (all competitions): WDWWWL
While Yermakovich was keen to suggest a different approach from BATE, Luis Enrique has been busy playing down Barca's tag as favourites to win at the Borisov Arena.
The Blaugrana coach claimed that "a lot of things have changed since" the teams last met in the Champions League and believes that BATE's first-half performance against Roma, when they raced into a 3-0 lead, is a sign of their improvement at this level.
Nevertheless, the holders have now scored in their last seven away games in this competition, including in a 1-1 draw against Roma last month.
However, Barca have struggled somewhat on their travels so far this season, losing two of their opening four La Liga games.
Furthermore, while Enrique's men have scored only one goal less than Real Madrid this term, they have also conceded 11 times. Only local neighbours Espanyol and newly-promoted Real Betis have inferior defensive records in the top half of the Primera Division.
Recent form: DW
Recent form (all competitions): WLWWLW
Meanwhile, BATE are still without the services of former Arsenal and Barcelona midfielder Aleksandr Hleb for Tuesday's game.
BATE Borisov possible starting lineup:
Chernik; Olekhnovich, Polyakov, Milunovic, Mladenovic; Aleksievich, Nikolic, A Volodko, Stasevich; Gordeichuk, Signevich
Barcelona possible starting lineup:
Bravo; Alves, Pique, Mascherano, Alba; Busquets, Rakitic, Sergi; Neymar, Suarez, Sandro
Head To Head
BATE go into this game still searching for a first victory over the Spanish champions, after two unsuccessful attempts.
In the first meeting at the Dinamo Stadion in 2011, Aleksandr Volodko put through his own net before Messi scored twice as Barca registered a 5-0 in Minsk.
We say: BATE 0-3 Barcelona
While BATE have shown this season they can beat one of the best teams in Europe, in the form of Roma, Barca's ability to score away from home in this competition should see the Catalans win comfortably.