Barca will be without the services of Luis Suarez after the Uruguay international picked up a calf injury during Saturday's clash with Levante, which forced the centre-forward off the field before the break.
Elsewhere, Sergio Busquets and Jordi Alba should both return having been named on the bench at the weekend, but an ongoing knee problem is once again expected to rule Samuel Umtiti out.
Arturo Vidal started against Levante but is expected to be replaced for this match, while Ivan Rakitic is desperately out of favour and is unlikely to be handed a starting role.
Antoine Griezmann is also struggling to find his best form for the Catalan giants, but the Frenchman should keep his spot in the final third alongside Lionel Messi, who finally appears to be over his injury troubles.
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Who will win Tuesday's Champions League clash between Barcelona and Slavia Prague?