The Catalan giants remain on course for a clean sweep of trophies at home and in Europe after a hugely impressive first campaign at the helm for boss Ernesto Valverde.
With a seven-point lead on Atletico Madrid at the top of La Liga and a Copa del Rey final meeting against Sevilla to look forward to in April, all focus is now on overcoming Chelsea in the last 16 of the Champions League.
Pique is wary of the threat the English champions pose, and concedes that defeat over two legs could act as a negative turning point in his side's season.
"Expectations are maximum," he is quoted as saying by Goal.com. "We go out as favourites, with a chance to win. I know the atmosphere is positive, very favourable, everything looks good, but I think we have to be more prudent.
"We have to learn from experience, what has happened in recent years, and know that one bad day could see you knocked out of the Champions League.
"A bad result against Chelsea could turn the good season we are having into one that's not so good. We know we are in a good position in the league and the Copa del Rey and we go to London in the Champions League looking to win, get through and progress in the competition."
Barcelona have faced Chelsea 12 times in the Champions League since 2000, winning three of those games compared to the Blues' four triumphs.