Their five-match unbeaten run has seen them move out of the La Liga relegation zone by one point, but they will face their toughest test for a month when they face Atletico.
Madrid suffered a blow to their aspirations of finishing in second place last week when they lost 2-1 to city rivals Real.
That left Atletico six points adrift in third position, but with fourth-placed side Real Sociedad as many as 10 points behind, they can afford to attack Deportivo for the three points.
They will be looking to striker Radamel Falcao to continue his prolific season in front of goal, after the Colombian scored his 26th goal in 30 appearances last weekend.
Deportivo La Coruna: WWWDD
Atletico Madrid: DDWWL
Possible starting lineups
Deportivo La Coruna: Aranzubia; Manuel Pablo, Kaka, Aythami, Silvio; Valeron, Aguilar, Juan Dominguez, Riki; Bruno Gama, Pizzi
Atletico Madrid: Courtois; Miranda, Juanfran, Filipe Luis, Godin; Gabi, Mario Suarez, Raul Garcia, Koke; Falcao, Diego Costa
Sports Mole says: 1-2