There is no getting away from the fact that Atletico have been short of their best in Spain's top flight this season, picking up just 12 wins from their 29 matches, which has left them some way off the top of the table.
Indeed, the gap from fourth-placed Atletico to leaders Barcelona is 15 points, but Simeone's side, having been sixth entering the lockdown period, are now just two points off third-placed Sevilla.
Real Sociedad will have the chance to reclaim fourth on Thursday night, but the capital giants will fancy their chances of claiming a Champions League spot for the 2020-21 campaign despite some disappointing form.
Simeone's team have only lost four of their 29 league games this term, which is the second-best record in the league behind Real Madrid. They have only lost once at the Wanda Metropolitano in La Liga this term, meanwhile, and impressively overcame Liverpool in the Champions League back in March.
Atletico played out a 1-1 draw with Athletic Bilbao on June 14 but returned to winning ways on Wednesday with a 5-0 success at Osasuna, where Portuguese attacker Joao Felix scored an impressive brace.
As for Valladolid, a record of seven wins, 12 draws and 10 defeats from their 29 matches has brought them 33 points, which is enough for 14th spot in the table at this stage.
Pucela are eight points clear of the relegation zone, meaning that it would be a surprise if they were pulled into trouble, even with a lot of football still be played in the coming weeks.
Sergio Gonzalez's side will also enter this match off the back of two positive results, having beaten Leganes and drawn with Celta Vigo in their two fixtures since the return of the season earlier this month.
Valladolid held Atletico to a goalless draw in the reverse match earlier this season, although they have not beaten the capital side away from home in Spain's top flight since February 2009.
Atletico La Liga form: DWDDDW
Atletico form (all competitions): WDDWDW
Valladolid La Liga form: LWLLWD
Hatem Ben Arfa is likely to come into Gonzalez's thinking for a possible spot in the final third, although a 4-4-2 formation is expected to see Sergi Guardiola and Enes Unal once again line up in attack.
Atletico possible starting lineup:
Oblak; Trippier, Savic, Gimenez, Lodi; Correa, Thomas, Saul, Koke; Morata, Felix
Valladolid possible starting lineup:
Masip; Moyano, Fernandez, Salisu, Martinez; Plano, Alcaraz, Michel, Suarez; Unal, Guardiola
We say: Atletico 2-0 Valladolid
Valladolid's away form has been fairly solid this season, picking up four wins and four draws from their 15 matches. Atletico will be full of confidence after Wednesday's win over Osasuna, though, and we expect the home side to put another three points on the board in routine fashion.