The Rojiblancos, who are currently second in the league table and into the semi-finals of the Champions League, face Getafe on Monday night knowing that victory will take them back to the summit.
"There are a few games to go to finish the league, but then, when the league started, we lived game by game and now more than ever," the Argentine quoted as saying by FourFourTwo.
"We should be enjoying what is happening. There are four Spanish teams in the semi-finals of the Europa League and the Champions League and we're trying to be top of the league.
"We are competing very well in the league. The league is moving forward and the team is in a nice position. But to maintain the same options we have today we have to play a great game [against Getafe]. We depend entirely on game by game."
Simeone was appointed manager of the Spanish club in 2011.