A win for Simeone's men would close the gap to just a point at the top of La Liga, but the Atleti boss is anticipating a tough game against Betis.
"Betis are a very good team that started well in the league and Thursday's result in Europe will give them a boost," Simeone told reporters.
"I imagine a tough game, it always is against Betis. We'll have to be very carefully against an opponent who has a lot of pace on the wings."
"We have to have a look who will be available because they have some knocks in defence."
Los Rojiblancos were beaten 1-0 by Espanyol last week.