Godin has been on the sidelines since injuring his thigh in the middle of last month and has not been included in the squad for Saturday's La Liga clash at home to Real Betis.
However, Simeone is hopeful that the experienced centre-back will return for the European tie against their La Liga rivals.
"Godin does not have the medical discharge, but he will probably get it on Sunday. He is working to evolve in the best way. The expectation is that by this Tuesday he will be in the best possible condition," Simeone told reporters.